An inherited defect in hepatic excretory function marked by an increase of serum bilirubin concentration, an excessive urinary excretion of abnormal proportions of a form of coproporphyrin, a retention of dark pigment by hepatocytes, and the nonvisualization of the gall bladder using a cholecystogram. Also called chronic idiopathic jaundice.

The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company.