Due to the congenital nature of neuronal migration disorders, most patients do not recover from their symptoms. The course of disease tends to be static.

a diverse group of congenital brain abnormalities that arise specifically from defective formation of the central nervous system .

The most well characterized genes include DCX on the X chromosome, responsible for double cortex syndrome, and LIS1 on chromosome 17, the first gene identified for lissencephaly.

Diagnosis is usually made by neuroimaging. CT scan or MRI of the brain will show the characteristic abnormality. MRI has better resolution and may detect polymicrogyria or small heterotopias more easily than CT.

The royal family's lineage can be traced back for generations.