Olopatadine
Drug Info:
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Olopatadine
Brand names: Pataday™, Patanol™
Chemical formula:
- Drug Forms:
- Olopatadine Hydrochloride Nasal spray, solution (below)
- Olopatadine Hydrochloride Ophthalmic drops, solution
- Espa�ol:
- Clorhidrato de Olopatadina Aerosol nasal, solución
- Clorhidrato de Olopatadina Gotas Oftalmicas, solución
Olopatadine Hydrochloride Nasal spray, solution
What is this medicine?
OLOPATADINE (oh loe pa TA deen) is a histamine blocker. It helps to relieve itching, running, and stuffiness in the nose. This medicine is used to treat nasal symptoms from allergies and other irritants.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•sores or ulcers in your nose
•an unusual or allergic reaction to olopatadine, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
This medicine is for use in the nose. Follow the directions on the prescription label. Do not use more often than directed. Ask your doctor or health care provider if you have any questions.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years of age for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medicine?
•alcohol
•medicines for depression, anxiety, or psychotic disturbances
•medicines for sleep
•narcotic medicines for pain
•other medicines for allergies like diphenhydramine
•phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•sores in the nose
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•changes in taste
•cough
•dry mouth
•headache
•nose bleeds
•nose or throat irritation
•tiredness
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 4 and 25 degrees C (39 and 77 degrees F). Throw away any unused medicine after the expiration date or after 240 sprays.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Related Videos:
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Olopatadine
Oxford A-Z of Medicinal Drugs:
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olopatadine
An antihistamine used for the treatment of seasonal allergic conjunctivitis. It is available as eye drops on prescription only.
Side effects:
include eye pain and irritation.
Precautions:
olopatadine should not be used while wearing contact lenses, and should be used with caution by women who are pregnant or breastfeeding. It may cause temporary blurring of vision, affecting the ability to drive or use machinery.
Proprietary preparation:
Opatanol.
| olmesartan, olanzapine, ointment | |
| olsalazine sodium, omalizumab, omega-3 fatty acid compounds |
Wikipedia on Answers.com:
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Olopatadine
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|
|---|---|
| Systematic (IUPAC) name | |
| {(11Z)-11-[3-(dimethylamino)propylidene]-6,11- dihydrodibenzo[b,e]oxepin-2-yl}acetic acid |
|
| Clinical data | |
| Trade names | Patanol |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a602025 |
| Pregnancy cat. | C |
| Legal status | ? |
| Routes | Ophthalmic, intranasal, oral |
| Pharmacokinetic data | |
| Half-life | 3 hours |
| Identifiers | |
| CAS number | 113806-05-6  |
| ATC code | S01GX09 R01AC08 |
| PubChem | CID 5281071 |
| DrugBank | DB00768 |
| ChemSpider | 4444528 |
| UNII | D27V6190PM |
| KEGG | D08293 |
| ChEMBL | CHEMBL1189432  |
| Chemical data | |
| Formula | C21H23NO3 |
| Mol. mass | 337.412 g/mol |
| SMILES | eMolecules & PubChem |
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 (what is this?) (verify) |
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Olopatadine hydrochloride is an antihistamine (as well as anticholinergic) and mast cell stabilizer, sold as a prescription eye drop (0.2% solution, Pataday (or Patanol S in some countries), manufactured by Alcon). It is used to treat itching associated with allergic conjunctivitis (eye allergies). Olopatadine hydrochloride 0.1% is sold as Patanol (or Opatanol in some countries). A nasal spray formulation is sold as Patanase, which was approved by the FDA on April 15, 2008.[1] It is also available as an oral tablet in Japan under the tradename Allelock, manufactured by Kyowa Hakko Kogyo.[2]
It should not be used to treat irritation caused by contact lenses. The usual dose for Patanol is 1 drop in each affected eye 2 times per day, with 6 to 8 hours between doses.
Its side effects may include headaches (7% of occurrence) burning and stinging (5%), dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pruritus, asthenia, cold syndrome, pharyngitis, rhinitis, sinusitis, and taste perversion.
There is potential for Olopatadine as a treatment modality for steroid rebound (red skin syndrome.) [3]
Olopatadine was developed by Kyowa Hakko Kogyo.[4]
References
- ^ Drugs.com, Alcon's Patanase Nasal Spray Approved by FDA for Treatment of Nasal Allergy Symptoms
- ^ Kyowa Hakko Kogyo Co., Ltd. (2007). "ALLELOCK Tablets 2.5 & ALLELOCK Tablets 5 (English)" (PDF). http://www.e-search.ne.jp/~jpr/PDF/KYOWA08.PDF. Retrieved 2008-08-10.
- ^ Tamura T, Matsubara M, Hasegawa K, Ohmori K, Karasawa A. (2005). "Olopatadine hydrochloride suppresses the rebound phenomenon after discontinuation of treatment with a topical steroid in mice with chronic contact hypersensitivity.". http://www.ncbi.nlm.nih.gov/pubmed/15649273.
- ^ Kyowa Hakko Kogyo Co., Ltd. (2002). "Company History". Company Information. Kyowa Hakko Kogyo Co., Ltd.. http://www.kyowa-kirin.co.jp/english/company/history/index.html. Retrieved 16 September 2010.
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