Olopatadine is having pH dependent solubility and at concentration above 0.3%, it would require formulation pH below 4.

Fluticasone is water insoluble and to have proper suspension if suspending agents used, it will result in phase separation at high concentration of Olopatadine and low pH.

Yes! As it's said in this site.

http://www.kyorin-pharm.co.jp/eg/ir/allelock.pdf

Olopatadine hydrochloride is an antihistimine but is usually prescribed as a nasal spray or an eyedrop. As a nasal spray it is usually given for "hay fever" or other allergies where the main symptoms are nasal. As an eyedrop it is prescribed when the eyes are red and itchy from allergies (not for an eye infection). It isn't normally given as a tablet since it is a very specific antihistamine which is most useful for nasal (nose) or eye symptoms of allergy.

Opatanol Eye Drop: A Comprehensive Guide

Opatanol eye drop, also known as olopatadine eye drops, play an important role in the treatment of various eye diseases. This medication is widely used to relieve symptoms associated with allergic conjunctivitis and provides relief to many people with eye irritation and discomfort. In this article, we explore the importance of olopatadine eye drops, explore alternative treatments, and discuss possible side effects to provide a comprehensive understanding of this drug. Today we here at Time Pharmacy will dive deep into its benefits and side effects.

Meaning of Opatanol eye drop:

olopatadine eye drops belong to the class of antihistamines. The active ingredient, olopatadine, works by blocking histamine receptors in the eyes and reducing the effects of histamine, a chemical released during an allergic reaction. This mechanism is particularly effective in relieving symptoms associated with allergic conjunctivitis, such as itching, redness, and tearing.

The importance of Opatanol eye drops lies in its ability to provide quick and long-lasting relief from allergic eye symptoms, which improves the overall quality of life of people suffering from allergic reactions. The ease of using the drug through eye drops also contributes to its widespread use and popularity among patients.