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Olopatadine is having pH dependent solubility and at concentration above 0.3%, it would require formulation pH below 4.

Fluticasone is water insoluble and to have proper suspension if suspending agents used, it will result in phase separation at high concentration of Olopatadine and low pH.

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Q: Problems occured in formulation of olopatadine and fluticasone propionate nasal spray?
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