Polyclonal antibody recognizes several epitopes on the target
protein while monoclonal antibody recognizes only single epitope,
hence monoclonal antibodies are more specific than polyclonal
antibodies. However, sometimes MAbs are not able to precipitate the
antigen because the epitope might need to be exposed on the surface
of the antigen to be recognized by the antibody. Since some of the
epitope might be hidden and it's a single epitope that is
recognized by the monoclonal antibody, the propability of the
antibody to reconize the epitope is lower compared with the
polyclonal antibody that recognizes several epitopes on the target
protein this is the reason for the tendency of polyclonal
antibodies to have cross-reaction as compared to MAbs. by Victor S
Gruezo Jr