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Severe combined immunodeficiency (SCID) is the most serious human immunodeficiency disorder(s). It is a group of congenital disorders in which both the humoral part of the patient's immune system and the cells involved in immune responses fail.

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An immunodeficiency syndrome.  Hereditary types are called SCID (severe combined immunodeficiency) and the acquired type (from HIV) is AIDS (acquired immunodeficiency syndrome).

Severe combined immunodeficiency, also known as Boy in the Bubble Syndrome, Alymphocytosis, Glanzmann-Riniker syndrome, Severe mixed immunodeficiency syndrome and Thymic alymphoplasia.