ADA
Common variable immunodeficiency is an immunodeficiency disorder characterized by a low level of antibodies. Patients with this disease are subject to recurring infections.
The main diagnostic test that distinguishes common variable immunodeficiency from other immunodeficiency diseases is the low antibody level despite the normal number of B cells. Antibody levels are tested in the serum
SCID is severe combined immunodeficiency disease/disorder and is diagnosed by performing a complete blood count (CBC). The values for all white blood cells will usually be very low to not found. This is genetic and untreatable at this time and will result in the foal's death within the first year of life, and usually in the first month of life, because it has no immune system and can't fight off any bacteria or viruses.
It indicates that the enzyme has a high affinity for the substrate.
A very low pH can break the hydrogen bonds in an enzyme which causes the shape of the enzyme to change shape making the enzyme unable to do it's job. This is called "denaturation" However some enzymes such as pepsin only work in a low pH (pepsin works best in a pH of about 3) so it does depend on the enzyme.
Renin
low temperatures
Low levels of ATP
Enzymes shows different enzyme activity in different pH value.If the pH is high or low than the optimum pH there is a decrease in the activity of the enzyme.But if the pH is very high or very low it may lead to the deactivation of the enzyme.
At low concentration of substrate , rate of enzyme action is directly proportional to conc. of substrate .
it would be low
At 0°C enzyme action is low because the movement of molecules is low. This causes the collision frequency between enzyme and substrate to be low. Increasing the temperature speed up the movement of molecules and thus the collision frequency increases therefore enzyme action increases. Human bio enzymes work best at 37 degrees Celsius. As the temperature raises the shape of the enzyme changes and the enzyme becomes denatured. Temperature above 50 degrees Celsius will denature most human enzymes.