In nursing, it is advocating for the client when they are unable to do so (ie. in a coma, or lost the ability to effectively communicate). Substitutive advocacy should only take place if the nurse has been previously informed by the patient of his/her wishes.

Call your play and formation, then turn off the playclock and make the substitution.

salazar was a portuguese dictator in the 1920s to 1930s. he created the new state which was the substitutive system for the democratic system

2-chloro-2-methylbutane

I think that pancreatic cells in the small intestine secrete pancreatic juices throughout their lifetime