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Succinyl-CoA

 
Medical Dictionary: suc·ci·nyl·co·en·zyme A
 
(sŭk'sə-nĭl-kō-ĕn'zīm')
n.

The condensation product of succinic acid and coenzyme A that is one of the intermediates in the Krebs cycle. Also called succinyl-CoA.

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Veterinary Dictionary: succinyl-CoA
 

A high energy intermediate metabolite formed in the Krebs cycle by the oxidation of α-ketoglutaric acid.

 
Wikipedia: Succinyl-CoA
Top
Succinyl-CoA
Identifiers
CAS number [604-98-8]
PubChem 1111
MeSH succinyl-coenzyme+A
Properties
Molecular formula C25H40N7O19P3S
Molar mass 867.608
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox references

Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA or SucCoA is a combination of succinic acid and coenzyme A.

Contents

Source

It is an important intermediate in the citric acid cycle, where it is synthesized from α-Ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.

It is also synthesized from propionyl CoA, the odd numbered fatty acid which cannot undergo beta-oxidation.[1] Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerized to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there.

Fate

It is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (succinate thiokinase).

Another fate of succinyl-CoA is porphyrin synthesis, where succinyl-CoA and glycine are combined by ALA synthase to form δ-aminolevulinic acid (dALA).

Formation

Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction, which requires vitamin B12 to occur, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.

References

  1. ^ Halarnkar PP, Blomquist GJ (1989). "Comparative aspects of propionate metabolism". Comp. Biochem. Physiol., B 92 (2): 227–31. doi:10.1016/0305-0491(89)90270-8. PMID 2647392. 




 
 

 

Copyrights:

Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Succinyl-CoA" Read more