Seems like it could be referring to up/down regulation of the receptors in your brain that give you effects from drugs. Downregulation is a way for your brain to adjust/protect itself.

also.. I'm da ish trick what what

== == Thyroid hormones have far more than just three effects on the body. Two major ones are (1) the upregulation of an electrolyte pump called the sodium-potassium pump and (2) synergism with the sympathetic nervous system.

Laryngopharyngeal reflux (LPR) refers to a relatively common disease in which gastric contents are refluxed into part of the upper GI tract and respiratory pathway. Studies have shown that the presence of LPR causes an upregulation of antibody secreting mucosal cells and stimulation of lymphoid tissue.

Up regulation is the process when there is an increase of receptors on the surface of cells making them more sensitive to agents such as hormones. This is generally associated with pregnancy because hormone levels vary all the time. Up regulation activity increases signalling the cells to prepare for labor and delivery.

Cancerous tumours are formed from cells which have had mutations in very specific genes which have allowed them to survive independantly of cells around them in the body. Some of these key genes code for growth factors and other proteins which affect normal body cells. Often the tumour cell mutations cause upregulation of these growth factors causing neighbouring healthy cells to be affected in unusual ways.