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Possibly a failing front wheel bearing.

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Q: 2001 Jeep Cherokee 4X4 has new tires When you drive down the road you hear a loud hum and feel a vibration When I turn wheel to right it stops to the left gets louder What could that be?
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What could be the problem if im getting a nasty vibration in the steering wheel and floor in a 2000 jeep Cherokee?

Drive-shaft out of balance? Bad Universal joint? Tire / wheel out of balance


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What causes a bad vibration on accelerating on a rear wheel drive pickup truck?

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What could be the cause of intermittent vibration on a grand Cherokee Laredo?

I would have all tires balanced. Make sure all lug nuts are torqued correctly. Check each wheel to make sure one is not bent. Check the drive shaft for worn U-Joints or a bent drive shaft. Check the exhaust system to see if some part is loose or vibrating against the frame. Check the engine/transmission mounts for a broken mount. If the vibration is coming from the rear replace the fuel filter. A fuel pump that is working hard can cause a vibration. It can also be a fuel pump that is failing.