Dealer says 60K
In average on 2006 highlander hybrid...you will probably get around 22.6 mpg.....that is an average in whole considering city/highway
You won't know it needs replacing - it fails catastrophically, without any symptoms. Factory recommended replacement mileage is 95,000 miles. If you have passed that mileage you are living on borrowed time.
160,000
The EPA mileage estimate for the 2013 Toyota Highlander is 20 mpg in the city, 25 mpg on the highway.
The EPA mileage estimate for the 2001 Toyota Highlander is 19 mpg in the city, 25 mpg on the highway.
The EPA mileage estimate for the 2002 Toyota Highlander is 19 mpg in the city, 25 mpg on the highway.
The EPA mileage estimate for the 2010 Toyota Highlander is 20 mpg in the city, 27 mpg on the highway.
The EPA mileage estimate for the 2008 Toyota Highlander is 18 mpg in the city, 24 mpg on the highway.
The EPA mileage estimate for the 2012 Toyota Highlander is 20 mpg in the city, 25 mpg on the highway.
The EPA mileage estimate for the 2009 Toyota Highlander is 20 mpg in the city, 27 mpg on the highway.
The EPA mileage estimate for the 2011 Toyota Highlander is 20 mpg in the city, 25 mpg on the highway.
The EPA mileage estimate for the 2005 Toyota Highlander is 19 mpg in the city, 25 mpg on the highway.