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A recessive gene located on the X chromosome is the cause of hemophilia in affected individuals. Males are more likely to have hemophilia than females because?
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∙ 7y ago
Males only have one copy of the X chromosome
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∙ 7y ago
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What chromosome is affected by meckel syndrome?
Meckel Syndrome (type 1)is an autosomal recessive trait carried on chromosome 17.
What is the role of sex chromosomes in the control of gender and inheritance of hemophilia?
There are two sex chromosomes - X and Y. A person with two X chromosomes is female and a person with one X chromosome and one Y chromosome is male. One sex chromosome is inherited from each parent, with the sperm determining a child's sex.Hemophilia is a sex-linked condition as these genes are located on a sex chromosome (i.e. Y chromosome). Males are hence more prone to hemophilia as they only have one X chromosome. The sons of a carrier female have a 50% chance of suffering from hemophilia. The daughters of a hemophiliac father and a carrier mother may be affected, where she receives an affected X from both parents.
Could two phenotypically normal parents have a child with Hemophilia A?
XhXh - with hemophilia XhXH- carrier of hemophilia
Is it a change in the chromosomes or a gene in hemophilia?
Hemophilia itself is really just a genetic disorder. It causes problems with blood coagulation and people with the disorder tend to bleed a lot if cut, hence the name "bleeders." The disorder is caused by a mutation in the factor VIII gene, leading to a deficiency in factor VIII. (Factor VIII is a protein that is associated with blood clotting.) The deficiency in the blood clotting factor causes the affected person's blood to clot improperly. The factor VIII gene is located on the X-chromosome and is transmitted by recessive inheritance. Males have an X-chromosome and and a Y-chromosome and females have two X-chromosomes. This means that females would only carry one of the mutant alleles for hemophilia and are said to be carriers. Females are usually found to be only carriers and rarely express hemophilia. Males, on the other hand, will receive one X-chromosome from their mother and a Y-chromosome from their father, leading to hemophilia.
What is the probability that their son has hemophilia?
Hemophilia is passed down from mother to son. It is extremely rare for a woman to have hemophilia. It is necessary, though, for a woman to be a carrier of the disorder for her son to acquire this disorder. Females have two X chromosomes whereas males only have one. When a boy is born, he takes one X chromosome from his mother and one Y chromosome from his father. Therefore, he can only get hemophilia through his mother. Example One: Mother(Carrier)+Father(Non-Affected)=50% chance of their son acquiring the disorder and 50% chance of their daughter being a carrier. Example Two: Mother(Non-Affected)+Father(Hemophiliac)=All sons will be non-affected and all daughters will be carriers.
What chromosome number is hemophilia on?
Hemophilia is a Sex-linked genetic disorder. It is found on the X chromosome of chromosome 23.A carrier for Hemophilia(represented by H(dominant) or h(recessive)) would look like this:XHXh(Female)*Males are not carriers for hemophilia-They are either affected or they're not*An affected person would look like this:XhXh(Female) XhY(Male)Someone who is neither a carrier nor affected would look like this:XHXH(Female) XHY(Male)
Is hemophilia a disorder?
The clinical answer would be yes, however there are many exceptions to the rule in the case of hemophilia. The trait for hemophilia is carried on the X chromosome and is often recessive. This being the case, since females have 2 X chromosomes, there is typically a dominant gene on their other X that corrects the disorder if one X carries the trait for hemophilia. Males, having only one X chromosome (paired with a Y chromosome) an only express the traits on the one X that they have. This being the case, a male with the trait for hemophilia on his X chromosome must be affected by it. In more recent years it has become understood that the trait for hemophilia is not as recessive as once thought. In many females the trait has shown incomplete or shared dominance with the otherwise normal gene. This often results in the female having low clotting factor levels and actually being considered a mild or moderate hemophiliac.
Which chromosome contains the gene for hemophilia?
The X chromosome. That's why it's more common in males; females have 2 X chromosomes, but males only have 1. So if a woman has the hemophilia mutation on one of her chromosomes, she probably won't be affected by it.
What gene is affected by type 1 diabetes?
Chromosome 2
Why could there never be a female hemophillia?
Hemophilia is an X-linked recessive disease which means the disease can manifest only if the genes on both chromosomes are affected. As males have only one X chromosome the disease always manifests. It is possible for a female to be affected but it is very rare.
What chromosome is affected by meckel syndrome?
Meckel Syndrome (type 1)is an autosomal recessive trait carried on chromosome 17.
Why Are males more often hemophiliac?
Hemophilia is a recessive, sex-linked, X chromosome disorder. It would have to be present on both X chromosomes to present in females. It only has to be present on the single X chromosome to present in males.
Why are men most likely to have hemophilia?
Since Hemophilia A is an "X Chromosome" disease and women have two "X" Chromosomes, women with only one "X" Chromosome with the disorder would be carriers of the disease but not affected by it. Women with both "X" Chromosomes with the disorder would be very rare.
What is the role of sex chromosomes in the control of gender and inheritance of hemophilia?
There are two sex chromosomes - X and Y. A person with two X chromosomes is female and a person with one X chromosome and one Y chromosome is male. One sex chromosome is inherited from each parent, with the sperm determining a child's sex.Hemophilia is a sex-linked condition as these genes are located on a sex chromosome (i.e. Y chromosome). Males are hence more prone to hemophilia as they only have one X chromosome. The sons of a carrier female have a 50% chance of suffering from hemophilia. The daughters of a hemophiliac father and a carrier mother may be affected, where she receives an affected X from both parents.
Could two phenotypically normal parents have a child with Hemophilia A?
XhXh - with hemophilia XhXH- carrier of hemophilia
What gene does hemophilia affect?
The gene that causes hemophilia is located on the X chromosome. A woman who gives birth to a child with hemophilia often has other male relatives who have hemophilia. Sometimes, a baby will be born with hemophilia when there is no known family history. This means the gene can be"hidden"( or passed down through several generations of female carriers without affecting any male members of the family) or the change in the X chromosome is new (a spontaneous mutation).
Is it a change in the chromosomes or a gene in hemophilia?
Hemophilia itself is really just a genetic disorder. It causes problems with blood coagulation and people with the disorder tend to bleed a lot if cut, hence the name "bleeders." The disorder is caused by a mutation in the factor VIII gene, leading to a deficiency in factor VIII. (Factor VIII is a protein that is associated with blood clotting.) The deficiency in the blood clotting factor causes the affected person's blood to clot improperly. The factor VIII gene is located on the X-chromosome and is transmitted by recessive inheritance. Males have an X-chromosome and and a Y-chromosome and females have two X-chromosomes. This means that females would only carry one of the mutant alleles for hemophilia and are said to be carriers. Females are usually found to be only carriers and rarely express hemophilia. Males, on the other hand, will receive one X-chromosome from their mother and a Y-chromosome from their father, leading to hemophilia.
