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No, but most macromolecules are organic molecules (with a backbone made of carbon atoms). But it is possible to synthetically create macromolecules with a backbone made of silicon atoms (i.e. the silicones), boron atoms (i.e. the boranes), and a few others. The atoms attached to the backbone or forming side branches extending away from the backbone can be any element on the Periodic Table.

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Q: Are all macromolecules formed from same elements?
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