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Yes, it can protect a creature or player from an indirect source of damage, such as Pyroclasm. So when Pyroclasm is put on the stack, you add Master Apothecary's ability to it, choosing the target. You may do this as many times as you want, and have untapped Clerics to pay the cost with. Then each ability will resolve, setting up a condition on those targets to prevent the next two damage they would be dealt. Finally Pyroclasm will resolve - all creatures will take 2 damage, but those that Master Apothecary used his effect on, will prevent it.

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Q: Can 'Master Apothecary' prevent damage from 'Pyroclasm' in Magic the Gathering?
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