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It can be applied directly to the hand. However, it is unlikely to have any effect due to absorption into the blood. Even with the microgram level dosages required to produce a psychotropic effect, transcutaneous (skin) absorption is expected to be minimal.

If a person is warm, sweaty, etc., the dilated blood vessels near the skin combined with the sweat allowing for easier absorption may actually make absorption possible.

However, ingestion is much more likely to be effective.

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