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If a creature's Toughness has been reduced, then the effect that reduced it will say when the effect lasts until - Infest lasts until the end of turn, some can last as long as a certain permanent remains in play. 'Regeneration' has no effect on reduced toughness.

Damage on the other hand is always removed at the end of turn, you don't need Regeneration to do it. Regeneration just allows it to happen at other times too, when lethal damage is received.

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Q: Can a creature regain all of its toughness at the end of a turn even if it doesnt have regeneration?
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