"Acetylcholinesterase" production results in the production of a glucosteroid inhibitor.
Acetylcholinesterase inhibitors, of course! These include ambinonium (Mytelase), physostigmine, neostigmine (Prostigmin, Vagostigmin), galantamine (Razadyne, Reminyl, Nivalin), pyridostigmine, Tacrin (Cognex), donepezil (Aricept), edrophonium (Tensilon, Enlon, Reversol) and rivastigmine (Exelon), and others.
Physostigmine is an inhibitor of acetylcholinesterase which breaks down acetylcholine in the synaptic cleft of the neuromuscular junction. It is used in the treatment of Alzheimer's and memory loss.
There are 3 different types of acetylcholinesterase inhibitors - short-acting, medium-duration and irreversible inhibitors, which differ in their interactions with the active site of acetylcholinesterase.=Neostigmine is a medium-duration acetylcholinesterase inhibitor that enhances cholinergic transmission in the central nervous system, autonomic nervous system and at neuromuscular junctions. Acetlycholinesterase inhibitors are an established therapy for Alzheimer's disease and dementia .=
When an acetylcholinesterase (AChE) inhibitor binds with acetylcholinesterase, regardless of whether it is reversible or irreversible, it prevents the ability of AChE to bind with acetylcholine (ACh) and break it down. Therefore, ACh accumulates in the synaptic gap, causing the postsynaptic neuron or muscle cell to fire/contract repeatedly. As this happens, a fatigue effect is reached due to depletion of chemical energy stores (ATP, etc.), and weakness results from the reduced ability of neurons/muscles to respond to further stimulation.
Acetylcholinesterase
Pyrethrins affect the nervous system of insects by causing multiple action potentials in the nerve cells by delaying the closing of an ion channel. Or a fancy way of saying seizure. Pyrethrins and pyrethroids act as contact poisons, affecting the insect's nervous system. Which is why they are so fast acting.
Acetylcholinesterase inhibitors: Reversible:1.Physostigmine -Miotic, cycloplegic and reduces IOT 0.25-0.5 % drops -Atropine, and antidepressant poisoning with predominant CNS manifestations (crosses BBB) 2.Neostigmine-Doesnt cross BBB, hence good for d.tubocurare muscle blockade -Myasthenia -Post op ileus -Decurarisation 3.Pyridostigmine-Similar but less potent and long acting than neostigmine. Better tolerated in myasthenic patients 4.Edrophonium -Dx of myasthenia -Cobra bites 5.Rivastigmine -Alzhiemers(?) Irreversible: -Mostly pesticides DFP,Malathoin,Parathoin,Sarin, Soman (Nerve gas) -Metrifonate(Antihelminthic drug)
neostigmine
Acetylcholinesterase
Acetylcholine is degraded by acetylcholinesterase
ACHe