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Anemia affects red blood cells usually, and doesn't always lower the immune system response but aplastic anemia (a.k.a bone marrow failure) causes the body to produce less red blood cells, WHITE blood cells, and platelets. Therefore, I believe, anemia can lower your ability to fight off infections (if the amount of white blood cell production is lowered). the above answer is true but people with sickle-cell anemia have a greater resistance to malaria. Also aplastic anemia patients have just as much troube as fighting a VIRUS as any other person.

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Q: Can anemia lower your ability to fight off infections?
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