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according to my Dr a female who is over the age of 13 and taking depakote will run a 90% chance of becoming infertile that being said i have bean on depakote since i was 12 i am now 20 and pregnant with my first child.

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14y ago
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12y ago

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Chronic toxicity studies in juvenile and adult rats and dogs demonstrated reduced spermatogenesis and testicular atrophy at oral doses of 400 mg/kg/day or greater in rats (approximately equivalent to or greater than the maximum human daily dose (MHD) on a mg/m2 basis) and 150 mg/kg/day or greater in dogs (approximately 1.4 times the MHD or greater on a mg/m2 basis). Fertility studies in rats have shown doses up to 350 mg/kg/day (approximately equal to the MHD on a mg/m2 basis) for 60 days to have no effect on fertility. The effect of valproate on testicular development and on sperm production and fertility in humans is unknown.

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Q: Can depakote cause infertility in males?
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