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yes, they will gladly use cotton balls to build a nest and keep warm. This is a bad idea if you keep them as pets though, especially if you breed them. the tiny cotton strands can get wrapped tightly around their limbs and cut off circulation, effectively amputating the limb if they can't get it off. adults stand a decent chance of gettting it off, but the babies can't and it doesn't take long for them to lose the limb. Also, the strands are so fine it is nearly impossible for you to assist with removing them without harming them.

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Q: Can mice use cotton balls for warmth?
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