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Please, see side effects of Pioglitazone on the related links. According to both of the related links, Pioglitazone could cause swelling or oedema, especially in the legs/anckles (pedal). This side effect is considered less common, but more serious, needing a consultation with your doctor. Further side effects are listed on the related links.

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Q: Can pioglitazone cause pedal oedema on prolonged use?
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