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Yes it can. According to the Centers for Disease Control and Prevention:

The live attenuated influenza vaccine viruses in LAIV (seasonal vaccine and 2009 H1N1 monovalent vaccine) can cause a positive result on a rapid influenza diagnostic test. The tests are designed to detect influenza viruses and cannot differentiate between live attenuated and wild-type influenza viruses. A positive test in a person who recently (in the previous 7 days) received LAIV and who also has an influenza-like illness could be caused by either LAIV or wild-type influenza virus.

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14y ago
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13y ago

Yes! It happened to me. I thought I was in for weeks of misery. Turns out just the flu!

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Q: Can the flu give a false positive for mono?
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