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I had an enlarged spleen and enlarged lymph nodes and it turned out that I had Mono.

I don't think your "spleen" has anything to do with your wisdom teeth coming in. But, in uncommon cases, infection to your wisdom teeth can sometimes cause enlarged lymph nodes, but only if the teeth are "impacted". A dental impaction is where an unearthed tooth is growing in crooked underneath the gumline. This also causes other dental problems such as crooked teeth. If the lymph nodes your are referring to are painless and are swelling with other symptoms, then you might have a serious condition, which also means you need to see a doctor immediately. The swelling in the lymph nodes in your neck are the ones to swell if your teeth are infected from an impaction. Also, only the lower teeth can cause lymph node swelling in your neck. The nodes will be tender, moveable, and causing pain in any way.

Any kind of severe infection in your mouth, including a wisdom tooth infection, can cause your lymph nodes to become larger.

The spleen should not be directly affected though.

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Q: Can wisdom teeth cause enlarged lymph nodes or an enlarged spleen?
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