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In all technicalities, you can. Dogs can breed with any other dog, provided they are fertile, and even some other non-dog species like coyote.

However, that's not to say you shouldbreed your dog. There's a lot of risk, bothfinanciallyand in health wise when breeding dogs, especially when breeding mutts that you can not predict.

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Q: Can you cross your Newfoundland x St. Bernard and your Mastiff x Bernese Mountain Dog?
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What dog breed starts with B and M?

Bernese Mountain Dog or Bull Mastiff


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