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It might make the drug more potent. The potency depends on how acidic the body is, so drinking baking soda (alkalizes body), more of the drug might be absorbed. Not sure about drinking it after taking a pill, but it seems the XR type will probably see some effects. It seems like a lot of baking soda could do some serious things to the body which I'm not aware of.

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Q: Can you drink baking soda after Adderall?
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While everyone metabolizes drugs differently, the average person only absorbs about half of the Adderall in an oral dose. How much actually gets in your blood depends on the pH level of your body, or how acidic or alkaline you are. The more acidic your body is, the less Adderall you'll absorb. Sodium Bicarbonate, which is better known as Baking Soda, is an alkalinizing agent. The instructions for use as an antacid are on the box, and taking it as recommended shortly before and/or with Adderall increases the effects and the duration of the Adderall. Basically, Baking Soda makes Adderall stronger for longer. That's assuming you can choke it down. Baking Soda is nasty. Good Luck, Kat


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