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It's highly unlikely that someone will develop leprosy from a medieval grave. The live mycobacteria are extremely difficult to keep alive even in a lab, and needs a specific temperature to grow in (which is why armadillos undersides and human nasal cavities are a good place for it to grow). Even human-to-human contact is difficult, requiring someone with huge bacterial load to transmit to someone who is immunocompromised, malnourished, etc.

With that said, it is important you take all precautions when dealing with human remains, assuming that they are infectious, no matter how old they are. Mask and gloves should be worn at the least.

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Q: Can you get leprosy digging a medieval grave?
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