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People do it all the time when they take Tylenol PM. The PM part that helps people sleep is the benedryl or aka diphenhydramine hydrochloride 25mg / tablet. So I take two Tylenol and two benedryl to get the same effect as a Tylenol PM and don't have to pay a ridiculous amount for the relief.

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14y ago
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15y ago

you should be able to take aleve and Benedrul since I have not had any adverse effets. However some people are allergic to Alleve because of the ingredients NSAIDS sometime cause allergic reactions such as hives swelling and itchy burning ect. Benedryl will make those symptoms go away then you know not to take alleve again but just in case keep benedryl handy

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10y ago

Theoretically yes, but it's certainly not advisable. Each has a sedative as an active ingredient, and taking the two amplifies that sedative effect. An average person, on occasion, would not be harmed with a single dose of NyQuil mixed with a single dose of Benadryl, but it will knock you out cold, so don't plan on sleeping eight hours and then waking up feeling refreshed. I'd imagine you'd sleep ten and then still feel drowsy. However, I'm not a pharmacist, this is a basic chemistry education I'm working with, so I highly suggest you ask your doctor first, since everyone has a different body chemistry. Also prolonged use could damage your liver and kidneys, so don't plan on doing this every night unless you like dialysis and liver transplants.

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15y ago

Yes, it is just ibuprofen and diphenhydramine, the same ingredients in Advil P.M.

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14y ago

YES! My doctor just told me on yesterday that benedryl is one of the safest medicines. I took it all throughout my pregnancy and I have a wonderful healthy baby!

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Q: Can you mix acetaminophen and Benadryl?
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