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Though it's hard to say, depending on which NyQuil you would use, as each NyQuil has different drugs and a combination of them in it (NyQuil Cough, NyQuil Cold & Flue, etc.), it doesn't seem like there would be an interaction between the two.

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6y ago
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9y ago

Always ask your pharmacist if your over the counter medications and prescriptions will interact. There is a problem with omeprazole and some other drugs. And pharmacists always tell you this for free.

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Q: Can you mix NyQuil and methotrexate?
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