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A good rule of thumb is that you should only take a maximum of 1000mg of acetaminophen (Tylonel) per 6 hours and up to 600 mg of ibuprofen (Advil) every 6 hours. Whether you combine these two medications should be recommended by your doctor, but it is relatively safe if you stay less than these amounts. Many doctors do prescribe ibuprofen along with codeine/APAP or hydrocodone/APAP. There are long term effects of taking too much of either, including liver or kidney issues.

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15y ago
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15y ago

Tylenol 3 contains Codeine, and opiate pro-drug, and acetaminophen -- a Non-Steroidal Anti-Inflamatory Drug, or NSAID. Advil is Ibuprofen and it too is an NSAID. The danger of comining these two very similar NSAIDs is that they're rough on the GI system and can also be rough on the liver. If you need more pain control, you might consider asking your doc for Tylenol 4's. In answer, yes -- you can mix them -- and the result isn't instantly deadly if you stick to a safe dosage. But over time, you're running a risk. This isn't the best way to handle pain control.

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9y ago

Aleve and Tylenol 3 are both used for pain. Aleve is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation. Tylenol 3 is the combination of acetaminophen and codeine. Codeine is considered to be a narcotic. It would probably be a good idea not to take the two medicines together even though they don't contain the same ingredients. It would be a good idea to seek the advice of a physician or your pharmacist.

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13y ago

There is Acetaminophen in Tylenol with Codeine #3 so there would be no point. You can do it, just don't exceed 4 grams (4,000 mg) of Acetaminophen in a 24 hour period.

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12y ago

Yes, in most cases these have been prescribed together for this very reason. However, take caution when mixing these drugs with pH balanced liquids.

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Q: Can you mix advile and Tylenol 3?
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