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Well you should be able to. You need the original sims 2 first to play, so i am guessing if the sims 2 game works on your computer, you should be able to play the sims 2 open for business. But before you go and buy it, I would make sure that you have enough space and stuff to play, just in case your computer can't take sims 2 the expansion packs and mess up your computer. Because the Sims 2 and all the exampion packs are very heavy on computers.

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Q: Can you play play the Sims 2 Open for Business on a Windows Vista computer?
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