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It's best to ask a veterinarian about the use of iodine on a guinea pig. However,

cornstarch or styptic powder can be applied to a guinea pig's injured nail.

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Q: Can you put iodine on a guinea pigs nail injury?
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Related questions

What do you do if your guinea pigs nail falls off?

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How can you cut your guinea pigs nails if when you try she squeals?

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