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Maximum recommended prescription strength does of ibuprofen is 800 mg. So taking any more than 4 200mg tablets at a time is not recommended. Furthermore after that 800mg dose your body doesn't really metabolize any more, and mostly you just end up peeing the excess out. To answer your question though, it's not harmful to take tylenol and ibuprofen together. They do not interact with each other in your body. Both can have liver complications, so don't do this long term however, and NEVER overdose on tylenol as it converts into a liver toxin and can kill you or cause severe liver damage.

For a toothache most of your pain is coming from inflammation, so the ibuprofen (which has an anti-inflammatory effect) will do a much better job than tylenol, which really isn't a preferred medication by most dentists.

As a practicing dentist however the most important thing to remember is that if you're in that much pain from a toothache it is NOT going to get better, only worse, and likely can lead to serious infection of your gums and jaw, which can become life threatening. So please see your dentist to get the cavity filled or the tooth removed, either way you'll be in much less pain than you are now.

Dr. McSurdy DMD

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12y ago
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14y ago

Yes- not for long periods of time but my fiance was prescribed 600 mg ibuprofan when his wisdom teeth were removed in addition to hyrocodine.

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11y ago

Doctors will regularly prescribe Ibuprofen at 600 to 800mg doses, but NEVER exceed 3000mg in 24 hours of any NSAD (Nonsteroidal anti-inflammatory drug).

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10y ago

In the UK the maximum recommended dose for Ibuprofen is 400mg, 3 times a day. Any more than this can only be approved by your Doctor or Dentist.

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14y ago

No. It relieves pain.

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Q: Can you take 1600 mg of ibuprofen and 325 mg of Tylenol together for a toothache?
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