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You may not realize it, but you are talking about 3 different drugs right now. When you say oxycodone 325mg, you are most likely referring to percocet, which is made up of oxycodone (the opiate) and acetaminophen (aka Tylenol). The most common dosage of each drug is Oxycodone 5mg, acetaminophen 325mg. So if you look at the prescription bottle, it will probably say "Oxycodone/APAP 5/325." APAP is an abbreviation for the chemical name for acetaminophen. The third medication you asked about is ibuprofen. This is the generic for advil and motrin. It is in the family of NSAIDs-Non-Steroidal Anti-Inflammatory Drugs. There are no significant interactions between ibuprofen-acetaminophen-oxycodone. More important are side effects and your reasons for needing all these medications. Most important side effects: Acetaminophen- liver toxicity if too much is taken, the general rule is no more than 4 grams per 24 hour period. This number is decreased in the presence of other factors, ie. malnutrition, chronic alcohol abuse, etc. But most people do not approach the limit and therefore, acetaminophen is a relatively benign drug. Ibuprofen can have significant side effects. It can cause gastric distress and bleeding, increased bruising of the skin throughout the body, and even kidney problems. 800 mg of ibuprofen is a very high dose, if you do take that much, please make sure to take it on a full stomach. Oxycodone, like other opiates, has risk of addiction and all of its problems. Other side effects include constipation, urinary retention, sedation, and acute toxicity leading to respiratory depression --> failure--> death. With all of this information, think about why you need this combination of medicines. If you have enough pain, whatever the cause is, I suggest you see a doctor for a thorough evaluation. If you have seen a doctor and received the percocet prescription, but its not enough so you are considering adding ibuprofen, go back to your doctor and tell him/her you are still in pain. Don't add to your pain regimen without your doctor's advice. There is a lot of information here, but I hope some of it answered your question.

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14y ago
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12y ago

Yes, ibuprofen is different than the Tylenol in the Oxycodone.

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11y ago

yes

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Q: Can you take 800mg ibuprofen with oxycodene 325mg for different reasons at the same time?
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