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Yes. They are from different drug classes and have different effects. Wellbutrin is an anti-depressant of the Dopamine Norepinephrine Reuptake Inhibitor class. Ativan is an anxyolitic drug and is a benzodiazepine. I use this combination - wellbutrin daily, and ativan as needed for anxiety and insomnia. It works well.

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Update: I must disagree with the answer above (whoever wrote it). If you look up Bupropion (a.k.a. Wellbutrin) on Wikipedia, then scroll down to "Contraindications", it states clearly that Wellbutrin should not be taken with any type of benzodiazepine (which is what Lorazepam - a.k.a. Ativan - is). So you should absolutely talk this over with a doctor instead of asking the internet. You might just get an "I don't see why not" guess from someone who may not truly know the answer. Bottom line - talk to your doctor before taking those two together!

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9y ago
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Vicky Shimkus

Lvl 1
2y ago
I've been taking Lorazepam as needed and for insomnia for about a year now. My Dr. then gave me Wellbutrin for depression. I questioned her about the combination and she assured me that it was ok. So far so good.
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9y ago

I just switched from cymbalta to wellbutrin, and I take seroquel 50mg every night, as well as Valium 5mg (not the same as ativan, but a benzo, so the same class of drugs) and it's been fine so far for me. I have a doctor closely monitoring my meds and he said the combo I'm now on is ok.

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Update by another user: If you look up Bupropion (a.k.a. Wellbutrin) on Wikipedia, then scroll down to "Contraindications", it states clearly that Wellbutrin should not be taken with any type of benzodiazepine (which is what Lorazepam - a.k.a. Ativan - is). So you should absolutely talk this over with a doctor instead of asking the internet. Or do what the above person is doing and have your doctor monitor very closely. Bottom line - talk to your doctor before taking those two together!

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Wiki User

14y ago

I take 300mg of Wellbutrin and 2mg of Ativan daily. Doesnt seem to be a problem. The ativan helps with agitation, jitters and sleeplessness caused by Wellbutrin.

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13y ago

Yes. Taking these two medications together is not contraindicated (except for individuals with seizure disorders or bulimia, as they should not be prescribed Wellbutrin).

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Q: Can you take Seroquel and Wellbutrin together?
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