Can you take Dihydrocodeine and buprenorphine together?

Answer 1

The answer is no. While buprenorphine is much more powerful than hydrocodone, it is a partial agonist meaning it will bind to the receptors in your brain and lock in, not allowing any other opiates to react until the buprenorphine has worn off. Combined with a buprenorphine tolerance, it may take individuals as long as 5-7 days before they can actually feel the analgesic effects of other opiates, as buprenorphine has a slightly longer half life than other known prescription opiate painkillers.

Answer 2

Firstly what are you trying to achieve. Do you mean can you take the two drugs together to enhance analgesia (pain relief)? Or do you mean can both be taken together recreationally?

If for pain analgesia- no. This is pointless. Buprenorphine is a 'stronger' opioid than dihydrocodeine (DHC) and the two together will not provide "extra" pain relief.

Recreationally- no. Again there isn't much point- buprenorphine binds so strongly to receptors that you wouldn't feel the effect of any additional DHC. But, if you are addicted to DHC and have it in your system (i.e. you are not withdrawing) then by taking buprenorphine you may precipitate withdrawal symptoms. I know this may not be easy to understand and I won't go into the pharmacology here but this is something to be very careful about. It's not just DHC- if you are addicted to any opioid (heroin, morphine, oxycodone) and you are using (not withdrawing), then taking buprenorphine may precipitate withdrawal. In contrast if you are an addict but you have not used for sometime and are suffering withdrawal symptoms, buprenorphine will alleviate the withdrawal. Sounds funny I know but buprenorphine works differently.

Answer 3

no dude you'll get sick as hell. you can't mix subs and opiates.

Edit: As mentioned above, Suboxone contains Naloxone, which can cause an overdose and make you very ill. Also, Suboxone blocks the affects of opiates in your system and you would not feel the "high" you would normally feel without the Suboxone being present. So...yes, you CAN, but no, you really SHOULDN'T!

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Naloxone has very low bioavailability sub-lingually, and so isn't a factor. It's there to prevent people from injecting Suboxone. With injection, naloxone bioavailability is 100% Since naloxone binds more aggressively than buprenorphine and other opiates to your receptors, you experience dope-sickness. If naloxone were absorbed sub-lingually, you would have the same experience.

As for your original question, yes you can take them together, but because buprenorphine binds more aggressively than most other opiates, it will mostly go to waste. It will not make you sick.

If you were to wait at least twenty-four hours after your last buprenorphine, (the active ingredient of Suboxone), dose, the other opiate would now be able to bind to receptors, as much of the buprenorphine will have released. You can safely do this three days in a row, then go back to Suboxone without any ill effects. Any longer, and you might have to transition again, as you did the first time you started buprenorphine.

Answer 4

Nop bad idea i learned this last week