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Yes. Excedrin PM (unlike its cousins - the other Excedrins) does not contain caffeine. It contains diphenhydramine (Benadryl) to help you fall asleep. So it will not react with Phentermine, which is a stimulant.

Phentermine stays in the system a long time. 16-31 hours is its half-life (which means it might take more than full day to work out of your system). So be careful in the daytime with other stimulants.

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Q: Can you take Excedrin PM for a headache at 12 am if you took Phentermine 12 hours earlier?
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