Can you take Wellbutrin and Fioricet headache medicine together?

Answer 1

The simple answer is NO, you shouldn't.

Excessive use or abrupt discontinuation of barbiturates and other sedatives after chronic ingestion may precipitate seizures in patients receiving Wellbutrin. Theoretically, barbiturates like Wellbutrin may also decrease the plasma concentrations and pharmacologic effects of Wellbutrin due to induction of hepatic CYP450 isoenzymes.

The pharmacological response to Wellbutrin should be monitored more closely whenever a barbiturate is added to or withdrawn from therapy, and the Wellbutrin dosage adjusted as necessary. Although barbiturates and other sedatives may be prescribed to treat agitation, anxiety, and insomnia associated with Wellbutrin use, patients should be alerted to the possibility of an increased risk of seizures during excessive exposure to these drugs. Patients should not attempt to alter the dosages or discontinue the medications on their own without consulting with your physician. The use of bupropion is contraindicated in patients undergoing abrupt discontinuation of sedatives.