Can you take advil PM and advil cold and sinus?

Answer 1

Short answer: yes, they can safely be combined in full, normal doses.

Advil Cold and Sinus is ibuprofen (NSAID analgesic) with pseudoephedrine/phenylephrine (nasal decongestant; the active ingredient in Sudafed), and Tylenol PM is acetaminophen (analgesic) with diphenhydramine (sleep aid; the active ingredient in Benadryl). Combining ibuprofen and acetaminophen is a little redundant, but perfectly safe. Both also have no significant reaction with either diphenhydramine or pseudoephedrine. Some people do report different reactions to both diphenhydramine and pseudoephedrine: some people are sedated by both, and some report excitability. Be sure to note your personal reactions for future reference.

Note that you'd probably save some money and take fewer unneccesary drugs by purchasing generic versions of each drug separately -- ibuprofen, acetaminophen, diphenhydramine, and pseudoephedrine. The first two are for pain (you can opt for the one you prefer), the third is for insomnia, and the fourth is for nasal congestion. That way, you can take only what you need.