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Yes; Benedryl is an anti-histamine that should not react with Vyvanse.

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14y ago
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12y ago

I do all the time, because I use the diphenhydramine (Benadryl) to sleep.

Beware of dehydration, however. Drink lots of water. Both will cause you to lose water.

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Q: Can you take Vyvanse and the sleep aid diphenhydramine HCI together?
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