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It depends on the antidepressant. Read the side affects. If there are possible cardiogenic, haematological or vascular side affects like decreased/increased heart rate, or they cause thirst/dehydration or anaemia then I would strongly recommend that you do not mix them with poppers, as poppers severly lowers your blood pressure and dehydrates you as the body is trying to excrete it. Of course stopping the antidepressants has its drawbacks and perhaps you might want to consider still taking the antidepressants even if you are hellbent on having poppers in moderation. Taking poppers with alcohol therefore not recommended either, but many people do it. Chronic use of poppers is bad for the cardiovascular system as it damages the vasculature in the body from causing recurrent vasodilation. Taking poppers if you have a heart condition is very dangerous because excess pressure put on the heart when the poppers are sniffed as is taking it with beta blockers. Death from the immediate affects of poppers is rare unless somehow manage to drink lots and lots of the stuff, but there has not been much research done on the long term affects of chronic heavy use. Overuse can lead to dependency on poppers/can't enjoy sex without poppers. The very short term faint feeling is caused by both the drop in blood pressure (vasodilation and dehydration) and the fact their chemicals attach to red blood cells and weaken the blood's ability to carry oxgyen. One short term effect is they kill white blood cells and so weaken your immune system for about 3 days after taking them (normally causing a chesty cough). I would think that the long term effects are possible weakness in vascular tone and function, one study suggested that poppers are mutagenic and carcinogenic, so there could perhaps be an increased risk of throat, trachea and lung cancer, and maybe a risk factor for other lung diseases caused by corrosive poppers constantly burning the lung tissue (perhaps COPD).This is particularly the case for people who dip and unlighted cigarette into the poppers and aspirate some of the liquid into their lungs and hence the chest infection. Their corrosive nature can also lead to mouth ulcers. As for taking them on antidepressants, I have done so myself on mirtazapine and citalopram with no adverse affects, however there has not been much research done in conjunction with this topic as to the pharmacutical effects it has on the body.

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11y ago
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