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Drug is available as ionised form and unionised for at particular pH. If unionsed drug concentartion is high at particular pH. The drug will be having better absorpation.
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A drug has pKa 5. at which PH it will be 99.9 percent ionized?
To determine at which pH a drug will be 99.9% ionized, we need to consider the Henderson-Hasselbalch equation. The pH at which a drug is 99.9% ionized can be estimated by finding the pH value that is one unit above the pKa of the drug. Therefore, in this case, the drug will be 99.9% ionized at a pH of 6.
Does pka changes with temperature?
pKa (dissociation constant) is variable with temperature.
The Ka of an unknown weak acid is 5.4 x 10 to the power of negative 10. Determine the pKa of the weak acid?
pKa = -log KapKa = -log 5.4x10^-10pKa = 9.27
How can you calculate pka valve if pH is given?
How can you calculate pka valve if ph is given?
What is the Ka for aspirin with a pka of 3.48?
All you need to do to get Ka is to take the antilog of the pKa.
Importance of pka value in drug absorption?
if Pka value is more for acidic drug,best side for absorption will be throughout the G.i.Tract.
How do you find the pka value of a drug?
pKa of drug can be determined from Handerson Hasselbatch equation., when conc. of salt become equal to acid i.e. at equivalence point when pH=pka then in H-H equn, pH=pka
Is amphetamine a basic or acidic drug?
Amphetamines are a weakly basic drug with a pKa of about 9.8
A drug has pKa 5. at which PH it will be 99.9 percent ionized?
To determine at which pH a drug will be 99.9% ionized, we need to consider the Henderson-Hasselbalch equation. The pH at which a drug is 99.9% ionized can be estimated by finding the pH value that is one unit above the pKa of the drug. Therefore, in this case, the drug will be 99.9% ionized at a pH of 6.
Will the drug be ionized if it's pKa lower than the physiological pH and why?
An acid in a base solution will ionize; a base in an acid will ionize. Like solutions do not ionize. When pKa is less than pH, around 99 percent to 100 percent of the drug will ionize.
Why doesn't the pH partition hyothesis work for strong electrolytes or nonelectrolytes?
Their absorption and excretion does not depend on their extent of ionization in an aqueous environment or pH and pKa.
What is definition of pka value and difference between pH and pKa?
A pKa value is a measurement used for bases and acids. The measurement pH applies to hydronium ion concentrations that are in a solution, whereas pKa only applies to determining the amount of dissociation an acid wants to do in a solution.
How do you know a drug is acidic or basic from pka value?
To be honest, sometimes it can be extremely difficult to choose which equation you should use depending on whether the solution is basic or acidic. But what I do know, is that when the pka is small then the solution is acidic, and when the pka is large then the solution is basic. "A weak acid has a pKa value in the approximate range −2 to 12 in water. Acids with a pKa value of less than about −2 are said to be strong acids. " this being said, its hard to distinguish whether a solution is acidic or basic since they both have such a wide range of pka values. but if you want just a general guideline then i would stick with the rule "high pka=basic, low pka=acidic
What is the pka of diisopropylamine?
pKa=40
How do you calculate pka?
how do you calculate pKa
What is the pka of bromoacetic acid?
pKa=2.86
What is pKa value of aminoacids?
The pKa values of Amino acids depends on its side chain. However, the protonated amine group (NH3+) tends to have a pKa greater than 8.8, whereas the carboxylic acid (COOH) tends to have a pKa of 1.8 - 2.8. If you keep your amino acid at a pH between this value, you will likely have a Zwitter ion.
