pKa of drug can be determined from Handerson Hasselbatch equation., when conc. of salt become equal to acid i.e. at equivalence point when pH=pka then in H-H equn, pH=pka
The pKa of rasagiline is approximately 8.55. This value indicates the pH at which half of the drug is in its ionized form and half is in its non-ionized form.
The pKa value of Doxofylline is approximately 4.22.
The pKa value of pyridine is 5.2.
To find the pKa from Ka, you take the negative logarithm (base 10) of the Ka value. The formula is pKa = -log(Ka). This conversion helps simplify comparisons of acid strength.
To be honest, sometimes it can be extremely difficult to choose which equation you should use depending on whether the solution is basic or acidic. But what I do know, is that when the pka is small then the solution is acidic, and when the pka is large then the solution is basic. "A weak acid has a pKa value in the approximate range −2 to 12 in water. Acids with a pKa value of less than about −2 are said to be strong acids. " this being said, its hard to distinguish whether a solution is acidic or basic since they both have such a wide range of pka values. but if you want just a general guideline then i would stick with the rule "high pka=basic, low pka=acidic
if Pka value is more for acidic drug,best side for absorption will be throughout the G.i.Tract.
The pKa of rasagiline is approximately 8.55. This value indicates the pH at which half of the drug is in its ionized form and half is in its non-ionized form.
The pKa value of Doxofylline is approximately 4.22.
The pKa value of pyridine is 5.2.
To find the pKa from Ka, you take the negative logarithm (base 10) of the Ka value. The formula is pKa = -log(Ka). This conversion helps simplify comparisons of acid strength.
To be honest, sometimes it can be extremely difficult to choose which equation you should use depending on whether the solution is basic or acidic. But what I do know, is that when the pka is small then the solution is acidic, and when the pka is large then the solution is basic. "A weak acid has a pKa value in the approximate range −2 to 12 in water. Acids with a pKa value of less than about −2 are said to be strong acids. " this being said, its hard to distinguish whether a solution is acidic or basic since they both have such a wide range of pka values. but if you want just a general guideline then i would stick with the rule "high pka=basic, low pka=acidic
The pKa value of Acebrophylline is approximately 1.8.
The pKa value of azithromycin is around 8.4.
The pKa value of H2O is approximately 15.7.
The pKa value of acetylacetone is approximately 8.9.
The pKa value of benzylamine is approximately 10.4.
The pKa value of protonated pyrrole is approximately 0.8.