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What is a Tensilon test?
Tensilon is the trade name for edrophonium chloride. The Tensilon test is an injection of edrophonium chloride used to diagnosis myasthenia gravis (MG).
What characteristics does an abnormal Tensilon test have?
An obvious increase in strength in weakened muscles strongly suggests the diagnosis of myasthenia gravis. The effect comes on very rapidly, and fades within minutes.
What is a musk antibody blood test for?
Myasthenia gravis
How does the edrophonium chloride test work when diagnosing myasthenia gravis?
In people with myasthenia gravis involving the eye muscles, the drug will briefly relieve weakness.
Atropine sulfate preoperatively?
atropine sulfate is used as an antidote of anticholinesterase meds administered on patients with myasthenia gravis. Atropine sulfate should be also made available when performing the Tensilon Test to reverse the effect of Edrophonium injection.
What is the single fiber electromyogram test to diagnose myasthenia gravis?
SFEMG is the most sensitive clinical test of neuromuscular transmission and shows increased jitter in some muscles in almost all patients with myasthenia gravis. Jitter is greatest in weak muscles.
Tensilon test?
DefinitionThe Tensilon test is a method to help diagnose myasthenia gravis.How the test is performedA drug called Tensilon (also called edrophonium) or a dummy medicine (inactive placebo) is given during this test. The health care provider gives the appropriate one through one of your veins (intravenously, through an IV). You may also be given a medication called atropine before receiving Tensilon so that you do not know you are receiving the drug.You will be asked to perform some repetitive muscular movements such as crossing and uncrossing your legs or getting up from a sitting position in a chair. Particular attention will be paid to whether your muscle strength is improved by the Tensilon.The test may be repeated and additional Tensilon may be given to help tell the difference between myasthenia gravis and other conditions.How to prepare for the testNo special preparation is usually necessary. However, you should follow any dietary restrictions or other directions prescribed by your health care provider.How the test will feelYou will feel a sharp prick as the IV needle is inserted. The drug may cause a feeling of a churning of the stomach or a slight feeling of increased heart rate, especially if Atropine is not given first.Why the test is performedThe test helps diagnosis myasthenia gravis, may aid in telling the difference between myasthenic and other similar neurological conditions, and may be used to monitor oral anticholinesterase therapy.What abnormal results meanIn myasthenia gravis, the muscles will improve immediately following the Tensilon. The maximum benefit only lasts a few minutes.In myasthenic crisis (worsening of the disease that requires anticholinesterase therapy), there is a brief improvement in the muscle strength.In cholinergic crisis (overdose of anticholinesterase), Tensilon will make the person even weaker.Additional conditions under which the test may be performed include Lambert-Eaton syndrome.What the risks areThe drug used during the test may cause side effects, including fainting or respiratory failure. Therefore the test must be done in a medically supervised setting.ReferencesVincent A, Newsom-Davis J. Disorders of neuromuscular transmission. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 448.
What is the edrophonium chloride test used in diagnosing myasthenia gravis?
The test involves the intravenous administration of edrophonium chloride, a drug that temporarily increases the levels of acetylcholine at the neuromuscular junction.
What is the repetitive nerve stimulation test to diagnose myasthenia gravis?
This test records weakening muscle responses when the nerves are repetitively stimulated, and helps to differentiate nerve disorders from muscle disorders.
How does a repetitive nerve stimulation test diagnose myasthenia gravis?
A significant decrement to RNS in either a hand or shoulder muscle is found in about 60% of patients with MG.
What precautions need to be taken when using the Tensilon test?
The Tensilon test may cause heart rhythm abnormalities, especially in those patients with preexisting conditions.
How is the Tensilon test done?
The Tensilon test involves the intravenous injection of a small amount of Tensilon. The needle is left in place. If no adverse reaction is observed within 30 seconds, an additional volume is injected. Results are apparent within one minute.
