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Itachi had an unknown illness that weakened him. Whatever illness this was, it was worsened by his abilities to a point where he could no longer sustain life (by using Mangekyo Sharingan and Susano'o over time). Before battling Sasuke, he also had been drained from giving a power to Naruto, making him exceptionally weaker for that battle. There are many theories about the illness he had, ranging from lung cancer to Tuberculosis, and even the chance it could be some random unknown illness caused by Susano'o or from his bloodline, or even from depression. He contracted this illness at some time after killing the Uchiha Clan. Sasuke DID NOT kill him, Itachi died from using Susano'o to get to Sasuke to give him his Mangekyo Sharingan. Summoning Susano'o basically lowers your life expectancy for every use; all these factors ended up killing Itachi (as well as Sasuke fighting him, but not being able to finish him off). Itachi had planned to die fighting Sasuke as well, so it is somewhat unclear during the battle what was or wasn't already planned to happen.

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Q: Did Itachi die from a bad disease?
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