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Yep...especially if you were a 'native american'. Smallpox was a major factor in the decimating of number of American Indians, as they caught it from non-natives.

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Q: Did smallpox effect new borns in the 1800s in the US?
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Smallpox had a far more devastating effect in the New World, where it occurred as epidemics. The first recorded smallpox outbreak in Latin America occurred in 1507, when Spanish explorers brought the disease to Hispaniola. The natives lacked immunity to smallpox and entire tribes were extinguished. The population of Hispaniola, estimated to be 300,000 in 1492, had reportedly decreased to less than a 1,000 by 1541. 4 During the following decades Spaniards were able to conquer the Aztecs and the Incas, who, despite their large armies, sooner or later succumbed to smallpox. Historians cite from 2 to 15 million Aztec deaths due to smallpox.5Smallpox moved northward from Mexico and westward from the eastern populations of the United States and Canada.4 By the mid-1800s, smallpox had decimated many Native American tribes from United States, Canada, and Alaska.


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