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Difference between allosteric and covalent modulation?

Updated: 4/28/2022
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Zarnafunnygal

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12y ago

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The 2 mechanisms to alter protein shape are allosteric and covalent modulation.

Allosteric: If the protein contains 2 binding sites, the noncovalent binding of a ligand to one site can alter the shape & characteristics of the other site.

-One binding site on an allosteric protein, the functional site, carries out the proteins physiological functions.

-The other binding site is the regulatory site, and the ligand that binds to it is called the modulator molecule because it changes the shape!

Covalent: Covalent bonding of charged chemical groups to some of the proteins side chains changes the shape and characteristics of the protein. Usually a phosphate group is covalently bonded, in the reaction called phosphorylation.

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Q: Difference between allosteric and covalent modulation?
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