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They have a different mode of action in inhibiting the transcription of the viral DNA. The NRTI is actually a nucleoside that incorporates into the viral DNA but it does not have a 3-hydroxyl group so it inhibits and halts the continued growth of the viral DNA chain. The NNRTI's bind to the reverse transcriptase and inhibit its movement.

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Q: Difference between nucleoside reverse trancriptase inhibitor and non nucleoside reverse transcriptase inhibitor?
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