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Not always. Saprophytic Mycobacteria are acid-fast positive and don't cause disease. The kinds of acid-fast organisms that do cause disease, like Mycobacterium tuberculosis, are more difficult to treat with antibiotics because of the large amounts of lipids in their cell walls so they do cause serious disease.

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Acid fast organism in sputum suggest that the patient is having the pulmonary tuberculosis. This is potentially treatable condition. When this organism is found in skin scrapping, it indicates that the person may have leprosy. This is mild disease of low virulence. In both the cases you have to take treatment for long period.

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Q: Do acid-fast organisms always suggest serious disease?
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Does presence of acid fast organisms in a clinical specimen always suggest serious clinical disease?

Acid fast organism in sputum suggest that the patient is having the pulmonary tuberculosis. This is potentially treatable condition. When this organism is found in skin scrapping, it indicates that the person may have leprosy. This is mild disease of low virulence. In both the cases you have to take treatment for long period.


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