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Brain cells start to die when you are in your late teens, though this makes no difference in the majority of cases because we have so many. The process accelerates after middle age (i.e. about 55), but doesn't generally speaking have a noticeable effect on most healthy people until they are in their seventies or even older. Some forms of substance abuse- for example, Alcoholism- increases the destruction of brain cells, which is why some chronic alcoholics are often brain-damaged as well.

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